Anti-Atrial Natriuretic peptide

Code: AB5490-I-100UL D2-231

Application

Research CategoryNeuroscience

Anti-Atrial Natriuretic peptide, Cat. No. AB5490-I, is a highly specific rabbit polyclonal antibody, that targets Natriuretic ...


read more

Your Price
€414.00 EACH
€509.22 inc. VAT

Application

Research CategoryNeuroscience

Anti-Atrial Natriuretic peptide, Cat. No. AB5490-I, is a highly specific rabbit polyclonal antibody, that targets Natriuretic peptides A and has been tested in Western Blotting and Immunohistochemistry (Paraffin).

Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Atrial Natriuretic peptide in rat heart and mouse heart tissue sections.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Natriuretic peptides A (UniProt: P01161; also known as CDD-ANF, ANP, Cardiodilatin, CDD, Cardiodilatin-related peptide, CDP, Prepronatriodilatin) is encoded by the Nppa gene (Gene ID: 24062) in rat. Atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP) are belong to the natriuretic peptide family. They are responsible for body fluid homeostasis and regulation of blood pressure. ANP is produced mainly by cardiac myocytes and is released in response to atrial stretch. Once in the circulation, ANP induces natriuresis, diuresis, and cause a reduction in blood pressure. In renal tissue ANP acts on receptors that increase glomerular filtration rate, reduce sodium reabsorption in the distal nephron, and diminish renin secretion. ANP has an intra-molecular ring structure connected by two cysteine residues and N-terminal and C-terminal extensions from it. ANP is produced with a signal peptide (aa 1-24) and a propeptide region (aa 25-122), which are cleaved to produce active hormone. It is cleaved by Corin by cleavage of Arg-Ser (aa 122-123) peptide bond. It can also be cleaved by membrane metalloendopeptidase between aa 129-130 that initiates its degradation and thereby regulate its activity.

Immunogen

Epitope: C-terminus

KLH-conjugated linear peptide corresponding to 28 amino acids from the C-terminal region of rat Natriuretic peptides A.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Concentration: Please refer to lot specific datasheet.

Physical form

Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Affinity Purified

Quality

Evaluated by Western Blotting in rat heart tissue lysate.

Western Blotting Analysis: A 1:2,000 dilution of this antibody detected Atrial Natriuretic peptide in rat heart tissue lysate

Specificity

This rabbit polyclonal antibody detects Natriuretic peptides A in rat and murine heart. It targets an epitope within 28 amino acids from the C-terminal region.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~17 kDa observed; 16.55 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

antibody formaffinity isolated antibody
antibody product typeprimary antibodies
biological sourcerabbit
clonepolyclonal
Gene Informationmouse ... Nppa(230899)
manufacturer/tradenameChemicon®
NCBI accession no.NP_006163.1
packagingantibody small pack of 25 µL
purified byaffinity chromatography
species reactivityrat, mouse
technique(s)western blot: suitable, immunohistochemistry: suitable (paraffin)
UniProt accession no.P01161
This product has met the following criteria to qualify for the following awards:



PROCEED TO CHECKOUT

HAVE AN ACCOUNT? LOGIN


GUEST CHECKOUT

Proceed as a guest. You will have the option to register to access exclusive pricing and stock availability features after checkout.